As a Noun:
1. Information and understanding about a subject, which someone has in their mind. English = knowledge.
Interactive:
1. Used alone in response to your addressee's comments or to interrupt your addressee to confirm understanding or to encourage them to continue. English = 'I know', 'Yeah!', 'Ugh huh', 'Hmmm' and so on.
As Modifier:
1. Used at the beginning of a sentence to introduce a new topic of conversation.