As a Noun:
1. Something that confuses you because you do not understand it. English = puzzle.
2. The feeling of confusion you get when you do not understand something. English = puzzlement.
3. A question, game, or toy which you have to think about carefully in order to answer it correctly or put it together properly. English = puzzle.
As a Verb or Adjective:
1. To be confused because you do not understand something. English = (be) puzzled, (be) perplexed.
2. To try hard to think of the answer to something or the explanation for something. English = puzzle over.
3. To scratch your head as a gesture of puzzlement or to show other people that you are puzzled.
Interactive:
1. Used alone to tell your addressee that you really do not understand what has been said or what has happened. English = 'What in the hell's going on?!', 'I haven't got a clue!', and so on.