As a Noun:
1. The state of being no good. English = lousiness, rottenness.
2. The feeling that you do not like someone or something and that you think it or they are wrong. English = disapproval.
3. The state of getting worse and worse in condition (especially in illness), or to become more difficult or unpleasant. English = deterioration.
4. The lack of success in achieving or doing something. English = failure.
As a Verb or Adjective:
1. To be extremely bad. English = (be) lousy.
2. To feel or show that you do not like someone or something and that you think it or they are wrong. English = disapprove.
3. To become worse in condition (especially in illness), or to become more difficult or unpleasant. English = deteriorate.
4. To become so bad that you do not succeed in doing what you are trying to do. English = fail.
Interactive:
1. Used alone to show you do not like someone or something. English = 'Down with it!', 'Down with you!', and so on.